CPCT and you
What is cancer?
As a result of constant cell division, damaged cells are repaired and worn-out cells are replaced. Each cell has a sensor that indicates when the cell division should stop and when it is time to be replaced by new cells. Cancer cells don’t abide by these rules, however. They multiply faster, make errors in copying and don’t listen to the sensor as they should. Moreover, they enter other organs which can then no longer function properly.
Some of these accumulations of cells – or tumors – are quickly discovered and can be removed. Others grow so rapidly that they have spread before being noticed.
You and the CPCT
Using a new technology called Next Generation DNA Sequencing we can now determine all major mutations in the DNA of the tumor (the profile) at once. With the aid of the latest DNA analysis techniques we aim to get more insight into the association of genetic defects in cancer cells and outcome to therapy in order to eventually give patients with metastasized cancer the best personalized treatment, based on the genetic information from the tumor’s DNA.
Because the tumor is constantly changing it is good to have insight into the DNA mutations before treatment starts. For this reason, we first perform a biopsy on the tumor (see also Frequently Asked Questions). From this biopsy we isolate the DNA and map the genetic defects. This is then the basis for deciding which treatment is best for you.
For those patients undergoing standard treatment, the major aim is to get insight whether the genetic make-up of a tumor can be used to predict to outcome to the therapy received. If so, and genetic profiles are identified that predict whether or not a patients benefits from a certain treatment, such genetic profiles can be used in the future to guide treatment decisions. For those patients for whom no standard treatments are available (anymore), we will do our utmost to involve you in pharmaceutical research that suits your DNA profile, once your DNA profile is known. By participating in this research you also contribute to an increased knowledge of cancer and the development of new treatment methods. While large-scale DNA research is not currently applied in regular diagnostics we do expect this to be the case for specific types of cancer within a few years.